4’-DMA-7,8-DHF Capsules | 4'-DMA-7,8-Dihydroxyflavone | Eutropoflavin

This is my limitless supplement, I tried taking it orally, and it had a mild effect, then I put it under my tounge, wow! I can feel it kick in, the first time I did this, I felt it within a few min. It helps be focus, and makes my interactions with people easy peasy, usually I avoid people, but with this stuff I don't worry about social stress, its not a thing anymore and the effect lasts after not taking it. I take it 3 days on two days off, I do this with most all nootropics. they last longer that way. Also it lasts me all day, it pairs well, with Sabroxy and Cognance.

It is an efficient and potent compound. Eutropoflavin has an elevating effect on mood and on neuroplasticity (focus and memory). Focus wise, it feels a bit more mood-elevating with effects (I'm not a medical doctor, it is only anecdotal). It works a very long time, with a very long half-life, so be sure to take it early in the morning or it may disrupt your sleep (I take it at 6 AM before work). Being potent, it may have adverse effects on some people (my girlfriend experienced mild nausea. Some people experiences small headaches). It may be one of the most potent and efficient Nootropics I've tried, a compound which really amazes me, but as most very efficient nootropics, be responsible : don't take too much of it (1 cap is fine) and don't stack it with a lot of things if you don't know what you are doing.

This is amazing, I'm normally lethargic, but I really get moving on this stuff. Take it in the morning, and an hour later you are ready to tackle everything thrown at you for the next 4 hours or so. The research is very interesting.

I can't recommend this nootropic enough. This nootropic WORKS and it works immediately. If you take one capsule sublingually, in the next minutes you will feel an improvement in mood and focus and a reduction in stress. If you're like me, the effect is very notable.

I love this stuff. I can feel it kicking in. I take it first thing in the morning sublingually because I understand that the long duration might disrupt sleep. I also believe that increased bdnf can mitigate sleep disruption so that I feel like I need less sleep when I feel like my bdnf levels are high I do think it slightly disrupts my sleep but that I aclimated to it over a couple weeks. I like to take breaks on the weekend but I'm thinking I might take this one every day going sometime soon. My mood and mental flexibility feels improved similar to other bdnf enhancing activities, but more so than most others. I think there's a libido increase too with this one. I wish they'd offer this as a powder or in since other form that better facilitates sublingual administration. The gel cap takes some time to dissolve and I'm trying to get this stuff into my brain ASAP so it can be metabolized by bedtime. This is maybe my favorite supplement next to polygala and lion's mane. I used to exercise hard every day to get my depressed brain out of is funk for an hour or two but with all of these bdnf enhancing supplements I feel that 'anything's possible' buzz all day long.

Takes a couple weeks of chronic use to make a noticeable difference. Stick with it to reap the benefits. Sleep may be affected initially, but the positive results starting kicking in over time. Taking it sublingually seems to be helpful for me. Mixing the powder in with some Calcium AKG seems to result in a pretty powerful antidepressant effect. Increased productivity, energy and optimism seems to be the result for me.

My wife and I are elderly and each takes 2 capsules of 4'-DMA-7,8-DHF, as a daily dietary supplement. Based on evidence from scientific studies, the supplement has beneficial properties related to brain function. One important property relates to memory formation. Memory formation, involving “synaptic plasticity” is defined as dynamic changes in structure of synapses and synaptic connections in a brain region mediating memory formation. An important mediator of synaptic plasticity in brain is a small protein, called Brain-Derived Neurotrophic Factor (BDNF). BDNF is secreted within brain and is not taken up readily from blood. BDNF interacts (binds) with an enzyme receptor to produce ultimate synaptic plasticity effects. Interestingly, the enzyme can be activated by a naturally occurring small plant molecule called 7,8 dihydroxyflavone (DHF), which, when given orally, can reach brain tissue. Nonetheless, blood borne DHF is largely eliminated by liver, so less becomes available for take-up in the brain. A synthetically modified DHF is 4'-Dimethylamino-7,8-dihydroxyflavone (4'-DMA-7,8-DHF), which also readily reaches brain tissue and has longer action duration.

This is a great product, I'm surprised to see such mixed reviews but I know everyone's chemistry is different. I really feel significant difference in my energy and awareness when i take this vs. when I do not. Once in awhile I'll take two capsules early in the morning when I'm swamped at work with great results (I don't recommend doing this regularly though). I believe it has a long half-life, so it's best to take early to avoid sleep interactions. It's on the pricey side but I recommend giving it a try.

My wife and I are elderly and take 4'-DMA-7,8-DHF, as a daily dietary supplement. Why do we take the supplement? Based on evidence from scientific studies, the supplement has beneficial properties related to brain function. One important property relates to memory formation. Memory formation, involving “synaptic plasticity” is defined as dynamic changes in structure of synapses and synaptic connections in a brain region mediating memory formation. An important mediator of synaptic plasticity in brain is a small protein, called Brain-Derived Neurotrophic Factor (BDNF). BDNF is secreted within brain and is not taken up readily from the blood. BDNF interacts with an enzyme receptor to produce ultimate synaptic plasticity effects. Interestingly, the enzyme can be activated by a naturally occurring plant molecule called 7,8 dihydroxyflavone (DHF), which, when given orally, can reach brain tissue. Nonetheless, blood borne DHF is largely eliminated by liver so less becomes available for take-up in the brain. A synthetically modified DHF is 4'-Dimethylamino-7,8-dihydroxyflavone (4'-DMA-7,8-DHF), which has more potent and longer action duration.

Decent at the start wears off quick.

This has repaired most of the brain fog I've been suffering from for the past year, but there are 2 major issues that need to be addressed if you're going to take it: 1. Headaches. You may need to supplement heavily with a choline source to avoid headaches. Citicholine and centrophenoxine are my go-tos but others should work. 2. Sleep. Numerous users have reported sleep issues with this because it remains bioactive for 8-12 hours, and I experienced this for about a week, but I've actually found that taking it shortly before bed results in better sleep with fewer interruptions than I've had in a very long time, which might be due to a rebound effect as it wears off (I speculate this may be also be related to how TRKB suppresses orexin-a). I'm also taking polygala as this seems to be a consistent factor for people that have had a good experience with this.

The compounds of this supplement were exactly what I was looking for and they work great. It's easiest to take these when you don't have anything else to do for the day, because they are hard on the digestion process.