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Dose
600mg (One Capsule)
Dose Timing
Flexible
How to Take
With Food
Dose Frequency
3 Times Daily
Berberine + Silymarin may improve lipid and glucose profiles, support cognitive function, boost immune health, and offer neuroprotective benefits through antioxidant and anti-inflammatory effects.
Time to notice full effects: 2-3 Weeks (With Acute Effects)
Metabolism
Cognition
Immune
Neuroprotection
Berberine is an alkaloid compound and ammonium salt that is found in various plants in the berberis genus. Berberine has a distinct bright yellow color and was widely used in traditional practices as a dye for various textiles. Berberine has an extensive history in Ayurveda, being used for promoting immune system function. Plants like Goldenseal (Hydrastis canadensis) and Chinese goldthread (Coptis chinensis) are natural sources of Berberine and have been used in Traditional Chinese practices and Ayurvedic practices.
Berberine actually has relatively low bioavailability when consumed orally. This is why we decided to combine Berberine with Silymarin for a uniquely bioavailable Berberine supplement! Research shows that this combination can further promote Berberine’s overall bioavailability and efficacy while also providing Silymarin benefits. When taken as a nootropic, Berberine carries various potential benefits to cognitive function and physical health. It will be beneficial to use Berberine with Silymarin so Berberine benefits can be achieved with a lower dose of Berberine.
Berberine may benefit both physical health and mental faculties. Early studies suggest that Berberine may regulate telomerase, a protein associated with the life cycle and proliferation of cells. Yet recent Berberine research leads toward AMPK modulation as one of Berberine’s primary mechanisms of action. AMPK, also known as Adenosine monophosphate kinase, is an enzyme that helps support cellular energy and has a role regulating cellular nutrients within cells. AMPK activation increases the uptake and breakdown of glucose through glycolysis. What also makes Berberine so interesting is that it may also slow down glucose production through gluconeogenesis. Some research finds that this may help promote optimal body composition and may help support exercise performance. Interestingly enough, this activity may play a role in the brain as well. Studies have shown that gluconeogenesis may help promote cognitive function.
Although it may be a more indirect effect on cognition, research finds that Berberine benefits to cognition might also be directly attributed to Berberine’s ability to activate sigma-1 receptors. Activation at these receptors raises BDNF levels and helps optimize NMDA activity. Research on BDNF activity found that decreased levels of BDNF may lead to low mood and diminished cognitive function, thus supporting evidence that Berberine may help promote overall cognitive function and positive mood. What also makes Berberine’s effects even more interesting is that BDNF and NMDA activity is also highly correlated to memory creation. Further research has also found that Berberine may help promote acetylcholine levels by regulating acetylcholinesterase, the enzyme that breaks down acetylcholine. By blocking acetylcholinesterase, Berberine may help promote higher acetylcholine levels in the brain. This in combination with AMPK modulation and sigma-1 receptor activation makes Berberine a great option for those looking for a well rounded and all natural nootropic!
AMPK activation also speeds up the breakdown of fatty acids through fatty acid oxidation. As an added bonus, AMPK activation has dual effects as it may also regulate fatty acid production by regulating fatty acid synthesis. Berberine AMPK activation suggests that there may be Berberine benefits on weight loss. However, research finds that taking a Berberine supplement alone will not promote significant weight loss compared to pairing a Berberine supplement with a healthy diet and exercise routine.
Silymarin is a bioactive compound found in Milk Thistle and has been found in research to promote metabolic function on its own, however, pairing Berberine with Silymarin would give you the metabolic benefits of both worlds. Studies have found that Silymarin helps promote the bioavailability of Berberine and supports some of its effects. Research found that the combination of Silymarin and Berberine largely promoted metabolic function and supported balanced oxidation and inflammation levels more than supplementing Berberine alone. Due to the enhanced bioavailability of Berberine, this combination allows for lower doses of Berberine to be used.
As a dietary supplement, take 1 Berberine HCL + Silymarin tablet three times daily, preferably 20 minutes before a meal.
To gain more insight, read the Berberine + Silymarin reviews and experiences below.
Nootropics Depot's Berberine HCL capsules has been lab-tested and verified for both product purity and identity.
You may also like Berberine HCL Powder.
| *Attention: This product is not intended to diagnose, treat, cure, or prevent any disease. It has not been approved, nor have these statements been evaluated, by the FDA. |
I had been taking the berberine liposomal for a while. Then I tried this. Oops. I have bile acid malabsorption so anything that increases bile causes issues for me. Milk thistle is well known for increasing bile, but I had forgotten about that. My blood sugar was actually a little lower on this product but I can't stand the side effect. So while this didn't work for me, I can say that it is potent. Enjoy if you don't have bile that can't recirculate properly.
It really does help after a carb-heavy meal. Although I sometimes have to take two. They make everything feel right again.
I took this with success before starting another supplement. Once on the other supplement, the fatigue knocked me for a loop. I realized the berberine was interacting, and paused it. Now I am about to discontinue the use of the other supplement and restart this to successfully control my blood sugar. I am so relieved to have this available to me as it works remarkably well.
As far as the product goes, it's fine. Seems to contain what it says, easy to take, no negative side effects. But like so many products like this, it's very difficult to know if it is actually working, since I can't self-diagnose "somewhat better metabolism." What I'd kill for is some high quality studies that could quantify the effect.
Excellent product. Unlike other Berberine I've tried in the past, this one does not cause me digestive discomfort. Will purchase again.
I bought for the glucose management properties that berberine provides and this provides it. Great product.
This works better than Thorne’s Berberine in my opinion. It’s made a huge difference in my stack, will always keep it as part of my supplement routine.
I just wish they'd keep it in stock!
No problems whatsoever dealing with this company
I love love love taking this stuff. If I ever have a heavy meal, I can pop one of these and I feel more fueled by my food than tired. It's awesome to have at my job after I eat like a carb heavy meal to work at my best. Haven't specifically used it to for weight loss since I know you need to diet for this to work for that.
Sometime after dosing of my first tab of berberine i began to experience sharp pain in my lower abdomen, but after the second dose not so much i still felt it but milder, and i noticed some potent stimulation also due to it's ampk effects nearly too much for my liking but effects would even out over time im guessing, im still undecided on this supplement though
I have been waiting for this to be back in stock to try it. So far, it has not disappointed! This is one of those versatile supplements that has a wide range of benefits found in other supps separately for both physical and mental health. I'm considering keeping this and taking it daily from now on.
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